Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins.

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作者： Maria Pia,Lenza ^[1] ; Iker,Oyenarte ^[1] ; Tammo,Diercks ^[1] ; Jon Imanol,Quintana ^[1] ; Ana,Gimeno ^[1] ; Helena,Coelho ^[2] ; Ana,Diniz ^[2] ; Francesca,Peccati ^[1] ; Sandra,Delgado ^[1] ; Alexandre,Bosch ^[1] ; Mikel,Valle ^[1] ; Oscar,Millet ^[1] ; Nicola G A,Abrescia ^[3] ; Asís,Palazón ^[4] ; Filipa,Marcelo ^[2] ; Gonzalo,Jiménez-Osés ^[1] ; Jesús,Jiménez-Barbero ^[5] ; Ana,Ardá ^[1] ; June,Ereño-Orbea ^[4]

作者单位： CIC bioGUNE, Basque Research and Technology Alliance, BRTA, Bizkaia Technology Park, 48162, Derio, Spain. ^[1] UCIBIO, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516, Caparica, Portugal. ^[2] CIC bioGUNE, Basque Research and Technology Alliance, BRTA, Bizkaia Technology Park, 48162, Derio, Spain.;Ikerbasque, Basque Foundation for Science, 48013, Bilbao, Spain.;Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. ^[3] CIC bioGUNE, Basque Research and Technology Alliance, BRTA, Bizkaia Technology Park, 48162, Derio, Spain.;Ikerbasque, Basque Foundation for Science, 48013, Bilbao, Spain. ^[4] CIC bioGUNE, Basque Research and Technology Alliance, BRTA, Bizkaia Technology Park, 48162, Derio, Spain.;Ikerbasque, Basque Foundation for Science, 48013, Bilbao, Spain.;Department of Organic Chemistry II, University of the Basque Country, UPV/EHU, 48940, Leioa, Spain. ^[5]

关键词 SARS-CoV2 glycan lectin molecular recognition receptor binding domain