Discovery of Covalent MKK4/7 Dual Inhibitor.

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作者： Jie,Jiang ^[1] ; Baishan,Jiang ^[1] ; Zhixiang,He ^[1] ; Scott B,Ficarro ^[2] ; Jianwei,Che ^[1] ; Jarrod A,Marto ^[3] ; Yang,Gao ^[1] ; Tinghu,Zhang ^[4] ; Nathanael S,Gray ^[5]

作者单位： Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. ^[1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. ^[2] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. ^[3] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address: tinghu_zhang@dfci.harvard.edu. ^[4] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address: nathanael_gray@dfci.harvard.edu. ^[5]

关键词 MKK4/7 breast cancer small-molecule kinase inhibitor target therapy

主题词氨基酸特征结构(Amino Acid Motifs);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);药物设计(Drug Design);人类(Humans);MAP激酶激酶4(MAP Kinase Kinase 4);MAP激酶激酶7(MAP Kinase Kinase 7);模型, 分子(Models, Molecular);蛋白激酶抑制剂(Protein Kinase Inhibitors)

DOI 10.1016/j.chembiol.2020.08.014

PMID 32916088

发布时间 2021-07-05

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Cell chemical biology

2020年27卷12期

1553-1560.e8页

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Discovery of Covalent MKK4/7 Dual Inhibitor.

Cell chemical biology

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Discovery of Covalent MKK4/7 Dual Inhibitor.

Cell chemical biology

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Cell chemical biology

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