Tissue-specific genetic features inform prediction of drug side effects in clinical trials.

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作者： Áine,Duffy ^[1] ; Marie,Verbanck ^[2] ; Amanda,Dobbyn ^[1] ; Hong-Hee,Won ^[2] ; Joshua L,Rein ^[3] ; Iain S,Forrest ^[1] ; Girish,Nadkarni ^[2] ; Ghislain,Rocheleau ^[4] ; Ron,Do ^[5]

作者单位： Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[1] Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[2] Université de Paris, UR 7537 BioSTM, Paris, France. ^[3] Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[4] Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea. ^[5] Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[6] Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ron.do@mssm.edu. ^[7]

主题词临床试验(主题)(Clinical Trials as Topic);全基因组关联研究(Genome-Wide Association Study);人类(Humans);表型(Phenotype);多态性, 单核苷酸(Polymorphism, Single Nucleotide);数量性状基因座位(Quantitative Trait Loci)

DOI 10.1126/sciadv.abb6242

PMID 32917698

发布时间 2024-06-28

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Science advances

2020年6卷37期

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Tissue-specific genetic features inform prediction of drug side effects in clinical trials.

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Tissue-specific genetic features inform prediction of drug side effects in clinical trials.

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