Acquisition of chromosome 1q duplication in parental and genome-edited human-induced pluripotent stem cell-derived neural stem cells results in their higher proliferation rate in vitro and in vivo.

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第一作者： Narges Zare,Mehrjardi

第一单位： Center for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany.;Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

作者： Narges Zare,Mehrjardi ^[1] ; Marek,Molcanyi ^[2] ; Firuze Fulya,Hatay ^[2] ; Marco,Timmer ^[3] ; Ebrahim,Shahbazi ^[4] ; Justus P,Ackermann ^[5] ; Stefan,Herms ^[6] ; Stefanie,Heilmann-Heimbach ^[7] ; Thomas F,Wunderlich ^[8] ; Nora,Prochnow ^[9] ; Aiden,Haghikia ^[9] ; Angelika,Lampert ^[10] ; Jürgen,Hescheler ^[2] ; Edmund A M,Neugebauer ^[11] ; Hossein,Baharvand ^[12] ; Tomo,Šarić ^[2]

作者单位： Center for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany.;Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. ^[1] Center for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany. ^[2] Department of Neurosurgery, University Hospital Cologne, Cologne, Germany. ^[3] Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. ^[4] Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany. ^[5] Department of Genomics, Life & Brain Center, Institute for Human Genetics, University of Bonn, Bonn, Germany.;Department of Biomedicine, Medical Genetics, Research Group Genomics, University Hospital Basel, Basel, Switzerland. ^[6] Department of Genomics, Life & Brain Center, Institute for Human Genetics, University of Bonn, Bonn, Germany. ^[7] Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.;Max Planck Institute for Metabolism Research and Institute for Genetics, University of Cologne, Cologne, Germany.;Cologne Cluster of Excellence in Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany. ^[8] Clinic for Neurology, St. Josef-Hospital, Clinic of the Ruhr-University Bochum, Bochum, Germany. ^[9] Institute of Physiology, Uniklinik, RWTH Aachen University, Aachen, Germany. ^[10] Medizinische Hochschule Brandenburg Theodor Fontane, Campus Neuruppin, Neuruppin, Germany. ^[11] Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.;Department of Developmental Biology, University of Science and Culture, Tehran, Iran. ^[12]

关键词 AAVS1 cell-based therapy chromosome aberrations differentiation duplication genome editing neurons regenerative medicine transplantation zinc-finger nuclease