A novel pathway for the induction of DNA damage in human spermatozoa involving extracellular cell-free DNA.

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作者： Robert John,Aitken ^[1] ; Sara,Whiting ^[2] ; Haley,Connaughton ^[2] ; Ben,Curry ^[3] ; Torsten,Reinheimer ^[4] ; Marcel,van Duin ^[5]

作者单位： Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia. Electronic address: John.Aitken@newcastle.edu.au. ^[1] Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia. ^[2] Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia; Ferring International PharmaScience Center, Copenhagen, Denmark; Ferring Research Institute, San Diego, CA, USA. ^[3] Ferring International PharmaScience Center, Copenhagen, Denmark. ^[4] Ferring Research Institute, San Diego, CA, USA. ^[5]

关键词 8-hydroxy-2' –deoxyguanosine, (8OHdG)Cell free DNA DNA damage DNA endonuclease Fertilization Mitochondrial metabolism Oxidative stress Spermatozoa Toll like receptor 9, (TLR9)

主题词动物(Animals);DNA损伤(DNA Damage);女(雌)性(Female);生育力(Fertility);人类(Humans);男(雄)性(Male);小鼠(Mice);氧化性应激(Oxidative Stress);精子能动性(Sperm Motility);精子(Spermatozoa)

DOI 10.1016/j.mrfmmm.2020.111722

PMID 32920458

发布时间 2020-12-14

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Mutation research

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A novel pathway for the induction of DNA damage in human spermatozoa involving extracellular cell-free DNA.

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A novel pathway for the induction of DNA damage in human spermatozoa involving extracellular cell-free DNA.

Mutation research

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Mutation research

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