Downregulation of miR-326 and its host gene β-arrestin1 induces pro-survival activity of E2F1 and promotes medulloblastoma growth.

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作者： Evelina,Miele ^[1] ; Agnese,Po ^[2] ; Angela,Mastronuzzi ^[1] ; Andrea,Carai ^[3] ; Zein Mersini,Besharat ^[4] ; Natalia,Pediconi ^[5] ; Luana,Abballe ^[4] ; Giuseppina,Catanzaro ^[4] ; Claudia,Sabato ^[4] ; Enrico,De Smaele ^[4] ; Gianluca,Canettieri ^[2] ; Lucia,Di Marcotullio ^[2] ; Alessandra,Vacca ^[4] ; Antonello,Mai ^[6] ; Massimo,Levrero ^[7] ; Stefan M,Pfister ^[8] ; Marcel,Kool ^[9] ; Felice,Giangaspero ^[10] ; Franco,Locatelli ^[11] ; Elisabetta,Ferretti ^[9]

作者单位： Department of Pediatric Hematology and Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. ^[1] Department of Molecular Medicine, Sapienza University, Rome, Italy. ^[2] Neurosurgery Unit, Department of Neurological and Psychiatric Sciences, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. ^[3] Department of Experimental Medicine, Sapienza University, Rome, Italy. ^[4] Center for Life NanoScience@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy. ^[5] Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, Italy. ^[6] Cancer Research Center of Lyon (CRCL), UMR Inserm 1052 CNRS 5286 Mixte CLB, Université de Lyon 1 (UCBL1), France. ^[7] Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy. ^[8] Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Heidelberg, Germany. ^[9] Department of Pediatric Oncology, Hematology and Immunology, University Hospital, Heidelberg, Germany. ^[10] Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. ^[11] Department of Radiological, Oncological and Pathological Science, Sapienza University, Rome, Italy. ^[12] IRCCS Neuromed, Pozzilli, Italy. ^[13] Department of Maternal Infantile and Urological Sciences, Sapienza University, Rome, Italy. ^[14]

关键词 ARRB1 E2F1 EZH2 medulloblastoma miR-326