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Combinatorial ETS1-dependent control of oncogenic NOTCH1 enhancers in T-cell leukemia.

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第一作者： Anna C,McCarter

第一单位： Cell and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan.

作者： Anna C,McCarter ^[1] ; Giusy,Della Gatta ^[2] ; Ashley,Melnick ^[1] ; Erin,Kim ^[3] ; Cher,Sha ^[3] ; Qing,Wang ^[3] ; Jahnavi K,Nalamolu ^[3] ; Yiran,Liu ^[4] ; Theresa M,Keeley ^[5] ; Ran,Yan ^[6] ; Mengxi,Sun ^[7] ; Rohan,Kodgule ^[8] ; Nicholas,Kunnath ^[9] ; Alberto,Ambesi-Impiombato ^[2] ; Rork,Kuick ^[10] ; Arvind,Rao ^[9] ; Russell J H,Ryan ^[8] ; Barbara L,Kee ^[7] ; Linda C,Samuelson ^[11] ; Michael C,Ostrowski ^[12] ; Adolfo A,Ferrando ^[13] ; Mark Y,Chiang ^[14]

作者单位： Cell and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan. ^[1] Institute for Cancer Genetics, Columbia University, New York, New York. ^[2] Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. ^[3] Stanford University, Stanford, California. ^[4] Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan. ^[5] Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. ^[6] Department of Pathology, University of Chicago, Chicago, Illinois. ^[7] Department of Pathology, University of Michigan, Ann Arbor, Michigan. ^[8] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan. ^[9] Department of Biostatistics, University of Michigan, Ann Arbor, Michigan. ^[10] Cell and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan.;Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan. ^[11] Medical University of South Carolina, Charleston, South Carolina. ^[12] Institute for Cancer Genetics, Columbia University, New York, New York. af2196@columbia.edu markchia@med.umich.edu.;Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.;Department of Pediatrics, Columbia University Medical Center, New York, New York.;Department of Systems Biology, Columbia University, New York, New York. ^[13] Cell and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan. af2196@columbia.edu markchia@med.umich.edu.;Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. ^[14]

关键词 ETS1 NOTCH1 T-ALL T-cell acute lymphoblastic leukemia T-cell development enhancer gamma-secretase inhibitors

医学主题词动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);白血病, T细胞(Leukemia, T-Cell);小鼠(Mice);前体T细胞淋巴母细胞白血病淋巴瘤(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma);原癌基因蛋白质c-ets-1(Proto-Oncogene Protein c-ets-1);受体, Notch1(Receptor, Notch1);信号传导(Signal Transduction)

DOI 10.1158/2643-3230.BCD-20-0026

PMID 32924017

发布时间 2022-05-31

基金项目

R35 CA210065/CA/NCI NIH HHS/United States R01 AI136941/AI/NIAID NIH HHS/United States P30 CA046592/CA/NCI NIH HHS/United States F30 CA228228/CA/NCI NIH HHS/United States P30 DK034933/DK/NIDDK NIH HHS/United States K08 CA208013/CA/NCI NIH HHS/United States P30 CA013696/CA/NCI NIH HHS/United States R01 DK118023/DK/NIDDK NIH HHS/United States T32 GM007315/GM/NIGMS NIH HHS/United States R01 AI106352/AI/NIAID NIH HHS/United States R01 CA196604/CA/NCI NIH HHS/United States

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Combinatorial ETS1-dependent control of oncogenic NOTCH1 enhancers in T-cell leukemia.

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