PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF-κB signaling.

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作者： Xinyi,Yang ^[1] ; Yanan,Wang ^[1] ; Panpan,Lu ^[1] ; Yinzhong,Shen ^[2] ; Xiaying,Zhao ^[1] ; Yuqi,Zhu ^[1] ; Zhengtao,Jiang ^[1] ; He,Yang ^[1] ; Hanyu,Pan ^[1] ; Lin,Zhao ^[1] ; Yangcheng,Zhong ^[1] ; Jing,Wang ^[1] ; Zhiming,Liang ^[1] ; Xiaoting,Shen ^[1] ; Daru,Lu ^[1] ; Shibo,Jiang ^[2] ; Jianqing,Xu ^[2] ; Hao,Wu ^[3] ; Hongzhou,Lu ^[2] ; Guochun,Jiang ^[4] ; Huanzhang,Zhu ^[1]

作者单位： State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China. ^[1] Department of Infectious Disease, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. ^[2] Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China. ^[3] UNC HIV Cure Center, Institute of Global Health and Infectious Diseases & Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ^[4]

关键词 CRISPR-Cas9 HIV latency NF-κB PEBP1 genome-wide screening

主题词 CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);HIV感染(HIV Infections);HIV-1(HIV-1);人类(Humans);NF-κB(NF-kappa B);磷脂酰乙醇胺结合蛋白质(Phosphatidylethanolamine Binding Protein);病毒潜伏期(Virus Latency)

DOI 10.15252/embr.201949305

PMID 32924251

发布时间 2022-05-31

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