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Can low-dose methotrexate reduce effusion-synovitis and symptoms in patients with mid- to late-stage knee osteoarthritis? Study protocol for a randomised, double-blind, and placebo-controlled trial.

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第一作者: Zhaohua,Zhu
第一单位: Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.;Department of Rheumatology and Clinical Immunology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.;Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
作者: Zhaohua,Zhu [1] ; Qinghong,Yu [2] ; Xiaomei,Leng [3] ; Weiyu,Han [4] ; Zhanguo,Li [5] ; Cibo,Huang [6] ; Jieruo,Gu [7] ; Yi,Zhao [8] ; Kang,Wang [9] ; Tianwang,Li [10] ; Yifang,Mei [11] ; Jianhua,Xu [9] ; Zhiyi,Zhang [11] ; David,Hunter [12] ; Flavia,Cicuttini [13] ; Xiaofeng,Zeng [3] ; Changhai,Ding [14]
作者单位: Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.;Department of Rheumatology and Clinical Immunology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.;Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. [1] Department of Rheumatology and Clinical Immunology, Zhujiang Hospital of Southern Medical University, Guangzhou, China. [2] Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. [3] Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. [4] Department of Rheumatology & Immunology, Peking University People's Hospital, Beijing, China. [5] Department of Rheumatology, Beijing Hospital, National Center of Gerontology, Beijing, China. [6] Department of Rheumatology, 3rd Affiliated Hospital of Sun Yet-Sen University Guangzhou, Guangzhou, Guangdong, China. [7] Department of Rheumatology & Allergy, Xuanwu Hospital, Capital Medical University, Beijing, China. [8] Department of Rheumatology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. [9] Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, China. [10] Department of Rheumatology, the First Affiliated Hospital of Harbin Medical University, Harbin, China. [11] Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.;Department of Rheumatology, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia. [12] Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. [13] Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Changhai.Ding@utas.edu.au.;Department of Rheumatology and Clinical Immunology, Zhujiang Hospital of Southern Medical University, Guangzhou, China. Changhai.Ding@utas.edu.au.;Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. Changhai.Ding@utas.edu.au.;Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Changhai.Ding@utas.edu.au. [14]
DOI 10.1186/s13063-020-04687-3
PMID 32938470
发布时间 2021-06-17
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