Can low-dose methotrexate reduce effusion-synovitis and symptoms in patients with mid- to late-stage knee osteoarthritis? Study protocol for a randomised, double-blind, and placebo-controlled trial.
第一作者:
Zhaohua,Zhu
第一单位:
Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.;Department of Rheumatology and Clinical Immunology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.;Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
作者:
医学主题词
老年人(Aged);双盲法(Double-Blind Method);人类(Humans);膝关节(Knee Joint);甲氨蝶呤(Methotrexate);多中心研究(主题)(Multicenter Studies as Topic);骨关节炎, 膝(Osteoarthritis, Knee);生活质量(Quality of Life);随机对照试验(主题)(Randomized Controlled Trials as Topic);滑膜炎(Synovitis);治疗结果(Treatment Outcome)
DOI
10.1186/s13063-020-04687-3
PMID
32938470
发布时间
2021-06-17
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Trials
795页
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