Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage.

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作者： Michelle A,Johnson ^[1] ; Qiudong,Deng ^[1] ; Georgia,Taylor ^[1] ; Zachary T,McEachin ^[2] ; Anthony W S,Chan ^[3] ; Jessica,Root ^[1] ; Gary J,Bassell ^[2] ; Thomas,Kukar ^[4]

作者单位： Department of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA, United States of America; Center for Neurodegenerative Disease, Emory University, School of Medicine, Atlanta, GA, United States of America. ^[1] Center for Neurodegenerative Disease, Emory University, School of Medicine, Atlanta, GA, United States of America; Department of Cell Biology, Emory University, School of Medicine, Atlanta, GA, United States of America; Laboratory of Translational Cell Biology, Emory University, School of Medicine, Atlanta, GA, United States of America. ^[2] Center for Neurodegenerative Disease, Emory University, School of Medicine, Atlanta, GA, United States of America; Department of Human Genetics, Emory University, School of Medicine, Atlanta, GA, United States of America; Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, 954 Gatewood Rd, NE, Atlanta, GA, United States of America. ^[3] Department of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA, United States of America; Center for Neurodegenerative Disease, Emory University, School of Medicine, Atlanta, GA, United States of America; Department of Neurology, Emory University, School of Medicine, Atlanta, GA, United States of America. Electronic address: Thomas.Kukar@emory.edu. ^[4]

关键词 Amyotrophic lateral sclerosis (ALS)Calicheamicin γ1 (CLM)DNA damage DNA-dependent protein kinase (DNA-PK)Frontotemporal dementia (FTD)Fused in sarcoma (FUS)Phosphorylation Species specific response