Vildagliptin, a DPP-4 inhibitor, attenuates carbon tetrachloride-induced liver fibrosis by targeting ERK1/2, p38α, and NF-κB signaling.

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第一作者： Rania,Khalil

第一单位： Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.

作者： Rania,Khalil ^[1] ; Ahmed,Shata ^[2] ; Eman M,Abd El-Kader ^[3] ; Hossam,Sharaf ^[4] ; Walied S,Abdo ^[5] ; Noha A,Amin ^[6] ; Sameh,Saber ^[7]

作者单位： Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt. ^[1] Department of Clinical pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; Department of Clinical Pharmacy, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt. ^[2] Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt. ^[3] Department of Clinical Pharmacy, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt. ^[4] Department of Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt. ^[5] Department of Haematology, Theodor Bilharz Research Institute, Egypt. ^[6] Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt. Electronic address: sameh.mohamed@deltauniv.edu.eg. ^[7]

关键词 ERK1/2 Fibrosis GLP-1R NF-κB Vildagliptin p38α

主题词动物(Animals);四氯化碳中毒(Carbon Tetrachloride Poisoning);细胞存活(Cell Survival);二肽基肽酶Ⅳ抑制剂(Dipeptidyl-Peptidase IV Inhibitors);剂量效应关系, 药物(Dose-Response Relationship, Drug);炎症介导素类(Inflammation Mediators);肝硬化(Liver Cirrhosis);肝功能试验(Liver Function Tests);MAP激酶信号系统(MAP Kinase Signaling System);男(雄)性(Male);小鼠(Mice);NF-κB(NF-kappa B);磷酰化(Phosphorylation);大鼠(Rats);信号传导(Signal Transduction);幸存(Survival);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)

DOI 10.1016/j.taap.2020.115246

PMID 32956689

发布时间 2021-01-08

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Toxicology and applied pharmacology

2020年407卷

115246页

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Vildagliptin, a DPP-4 inhibitor, attenuates carbon tetrachloride-induced liver fibrosis by targeting ERK1/2, p38α, and NF-κB signaling.

Toxicology and applied pharmacology

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Toxicology and applied pharmacology

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Vildagliptin, a DPP-4 inhibitor, attenuates carbon tetrachloride-induced liver fibrosis by targeting ERK1/2, p38α, and NF-κB signaling.

Toxicology and applied pharmacology

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Toxicology and applied pharmacology

相关期刊

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