Donepezil provides neuroprotective effects against brain injury and Alzheimer's pathology under conditions of cardiac ischemia/reperfusion injury.

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作者： Benjamin,Ongnok ^[1] ; Thawatchai,Khuanjing ^[2] ; Titikorn,Chunchai ^[1] ; Sasiwan,Kerdphoo ^[3] ; Thidarat,Jaiwongkam ^[3] ; Nipon,Chattipakorn ^[1] ; Siriporn C,Chattipakorn ^[4]

作者单位： Neuroelectrophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai 50200, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Chiang Mai University, Chiang Mai 50200, Thailand. ^[1] Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai 50200, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Chiang Mai University, Chiang Mai 50200, Thailand. ^[2] Neuroelectrophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Chiang Mai University, Chiang Mai 50200, Thailand. ^[3] Neuroelectrophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai 50200, Thailand; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address: siriporn.c@cmu.ac.th. ^[4]

关键词 Acetylcholinesterase inhibitor Alzheimer's disease Brain Cardiac ischemia/reperfusion injury Donepezil Mitochondria Neuroinflammation

主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);血脑屏障(Blood-Brain Barrier);脑损伤(Brain Injuries);疾病模型, 动物(Disease Models, Animal);人类(Humans);男(雄)性(Male);心肌再灌注损伤(Myocardial Reperfusion Injury);神经保护药(Neuroprotective Agents);氧化性应激(Oxidative Stress);大鼠(Rats);大鼠, Wistar(Rats, Wistar)

DOI 10.1016/j.bbadis.2020.165975

PMID 32956775

发布时间 2021-04-13

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Biochimica et biophysica acta. Molecular basis of disease

2021年1867卷1期

165975页

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Donepezil provides neuroprotective effects against brain injury and Alzheimer's pathology under conditions of cardiac ischemia/reperfusion injury.

Biochimica et biophysica acta. Molecular basis of disease

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Biochimica et biophysica acta. Molecular basis of disease

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Donepezil provides neuroprotective effects against brain injury and Alzheimer's pathology under conditions of cardiac ischemia/reperfusion injury.

Biochimica et biophysica acta. Molecular basis of disease

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Biochimica et biophysica acta. Molecular basis of disease

相关期刊

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