Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington's disease mice.

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第一作者： Giulia,Birolini

第一单位： Department of Biosciences, University of Milan, Milan, Italy.;Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi", Milan, Italy.

作者： Giulia,Birolini ^[1] ; Marta,Valenza ^[1] ; Eleonora,Di Paolo ^[1] ; Elena,Vezzoli ^[1] ; Francesca,Talpo ^[2] ; Claudia,Maniezzi ^[2] ; Claudio,Caccia ^[3] ; Valerio,Leoni ^[4] ; Franco,Taroni ^[3] ; Vittoria D,Bocchi ^[1] ; Paola,Conforti ^[1] ; Elisa,Sogne ^[5] ; Lara,Petricca ^[6] ; Cristina,Cariulo ^[6] ; Margherita,Verani ^[6] ; Andrea,Caricasole ^[6] ; Andrea,Falqui ^[5] ; Gerardo,Biella ^[2] ; Elena,Cattaneo ^[1]

作者单位： Department of Biosciences, University of Milan, Milan, Italy.;Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi", Milan, Italy. ^[1] Department of Biology and Biotechnologies, University of Pavia, Pavia, Italy. ^[2] Unit of Medical Genetics and Neurogenetics, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Milan, Italy. ^[3] School of Medicine and Surgery, Monza and Laboratory of Clinical Pathology, Hospital of Desio, ASST-Monza, University of Milano-Bicocca, Milan, Italy. ^[4] Biological and Environmental Science & Engineering (BESE) Division, NABLA Lab, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. ^[5] Neuroscience Unit, Translational and Discovery Research Department, IRBM S.p.A, Rome, Italy. ^[6]

关键词 Huntington's disease aggregates behavior cholesterol synapses