Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease.

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作者： Ana M,de Matos ^[1] ; M Teresa,Blázquez-Sánchez ^[1] ; Andreia,Bento-Oliveira ^[1] ; Rodrigo F M,de Almeida ^[1] ; Rafael,Nunes ^[1] ; Pedro E M,Lopes ^[2] ; Miguel,Machuqueiro ^[2] ; Joana S,Cristóvão ^[2] ; Cláudio M,Gomes ^[2] ; Cleide S,Souza ^[2] ; Imane G,El Idrissi ^[3] ; Nicola A,Colabufo ^[4] ; Ana,Diniz ^[4] ; Filipa,Marcelo ^[5] ; M Conceição,Oliveira ^[5] ; Óscar,López ^[6] ; José G,Fernandez-Bolaños ^[7] ; Philipp,Dätwyler ^[7] ; Beat,Ernst ^[8] ; Ke,Ning ^[8] ; Claire,Garwood ^[9] ; Beining,Chen ^[9] ; Amélia P,Rauter ^[3]

作者单位： Centro de Química Estrutural, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Lisboa 1749-016, Portugal. ^[1] Biosystems & Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Lisboa 1749-016, Portugal. ^[2] Department of Chemistry, The University of Sheffield, Dainton Building, Brook Hill, Sheffield S3 7HF, United Kingdom. ^[3] Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari "A. Moro", Via Orabona, 4, 70125 Bari, Italy. ^[4] UCIBIO, REQUIMTE, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica 2829-516, Portugal. ^[5] Mass Spectrometry Facility at CQE, Insituto Superior Técnico, Av. Rovisco Pais, Lisboa 1049-001, Portugal. ^[6] Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, Sevilla E-41071, Spain. ^[7] Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, Basel CH-4056, Switzerland. ^[8] Department of Neuroscience, Sheffield Institute for Translational Neuroscience, The University of Sheffield, Sheffield S10 2HQ, United Kingdom. ^[9]