Promotion of CTL epitope presentation by a nanoparticle with environment-responsive stability and phagolysosomal escape capacity.

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作者： Shuyun,Dong ^[1] ; Sundharraman,Subramanian ^[2] ; Kristin N,Parent ^[2] ; Mingnan,Chen ^[3]

作者单位： Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA. ^[1] Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA. ^[2] Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: mingnan.chen@utah.edu. ^[3]

关键词 Cytotoxic T lymphocyte vaccine Dendritic cells Epitope MHC class I Nanoparticle Phagolysosomal escapes Polypeptide materials Redox environment-responsive Self-assembly Vaccine carrier

主题词弹性蛋白(Elastin);表位, T淋巴细胞(Epitopes, T-Lymphocyte);纳米粒子(Nanoparticles);肽类(Peptides);T淋巴细胞, 细胞毒性(T-Lymphocytes, Cytotoxic)

DOI 10.1016/j.jconrel.2020.09.033

PMID 32961248

发布时间 2023-11-14

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