Methylisoindigo and Its Bromo-Derivatives Are Selective Tyrosine Kinase Inhibitors, Repressing Cellular Stat3 Activity, and Target CD133+ Cancer Stem Cells in PDAC.

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作者： Jana,Tegethoff ^[1] ; Roland,Bischoff ^[2] ; Sawsan,Saleh ^[1] ; Biljana,Blagojevic ^[1] ; Karl-Heinz,Merz ^[2] ; Xinlai,Cheng ^[1]

作者单位： Department of Pharmacy and Molecular Biotechnology, Division of Pharmaceutical Biology, University of Heidelberg, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany. ^[1] Department of Chemistry, Division of Food Chemistry and Toxicology, University of Kaiserslautern, Erwin-Schrödinger-Strasse 52, D-67663 Kaiserslautern, Germany. ^[2]

关键词 Stat3 inhibitor TCM cancer stem cells indirubin meisoindigo selective protein kinase inhibitor structure-activity-relationship

DOI 10.3390/molecules22091546

PMID 32961646

发布时间 2020-10-01

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