Molecular Mechanism of HER2 Rapid Internalization and Redirected Trafficking Induced by Anti-HER2 Biparatopic Antibody.

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作者： Jackie,Cheng ^[1] ; Meina,Liang ^[1] ; Miguel F,Carvalho ^[2] ; Natalie,Tigue ^[2] ; Raffaella,Faggioni ^[1] ; Lorin K,Roskos ^[1] ; Inna,Vainshtein ^[1]

作者单位： Integrated Bioanalysis, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, South San Francisco, CA 94080, USA. ^[1] Antibody Discovery & Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Granta Park, Cambridge CB21 6GH, UK. ^[2]

关键词 HER2 antibody internalization biparatopic antibody bispecific intracellular trafficking protein degradation

DOI 10.3390/antib9030049

PMID 32961882

发布时间 2020-11-03

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Antibodies (Basel, Switzerland)

2020年9卷3期

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Molecular Mechanism of HER2 Rapid Internalization and Redirected Trafficking Induced by Anti-HER2 Biparatopic Antibody.

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Molecular Mechanism of HER2 Rapid Internalization and Redirected Trafficking Induced by Anti-HER2 Biparatopic Antibody.

Antibodies (Basel, Switzerland)

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Antibodies (Basel, Switzerland)

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