Coordination Mechanism and Bio-Evidence: Reactive γ-Ketoenal Intermediated Hepatotoxicity of Psoralen and Isopsoralen Based on Computer Approach and Bioassay.

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第一作者： Yue,Hai

第一单位： School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Nankai District, Tianjin 300193, China.

作者： Yue,Hai ^[1] ; Shan,Feng ^[1] ; Lili,Wang ^[2] ; Yetao,Ma ^[1] ; Yiran,Zhai ^[1] ; Zijun,Wu ^[1] ; Sichao,Zhang ^[1] ; Xin,He ^[1]

作者单位： School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Nankai District, Tianjin 300193, China. ^[1] College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing 400715, China. ^[2] Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China. ^[3]

关键词 CYP3A4 GSH depletion coordination compound furanoepoxide hepatoxicity molecular docking γ-ketoenal intermediate

DOI 10.3390/molecules22091451

PMID 32962321

发布时间 2020-10-01

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