Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers.
作者:
主题词
黄曲霉毒素B1(Aflatoxin B1);动物(Animals);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);肝细胞(Hepatocytes);人类(Humans);半数致死量(Lethal Dose 50);肝移植(Liver Transplantation);男(雄)性(Male);小鼠(Mice);小鼠, SCID(Mice, SCID);RNA, 小分子干扰(RNA, Small Interfering);移植嵌合体(Transplantation Chimera);空泡(Vacuoles)
DOI
10.1371/journal.pone.0239540
PMID
32966316
发布时间
2020-11-09
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PloS one
e0239540页
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