首页> Cell chemical biology> Identification of Small-Molecule Activators of the Ubiquitin Ligase E6AP/UBE3A and Angelman Syndrome-Derived E6AP/UBE3A Variants.

Identification of Small-Molecule Activators of the Ubiquitin Ligase E6AP/UBE3A and Angelman Syndrome-Derived E6AP/UBE3A Variants.

导出 LinkOut

翻译打印收藏纠错

第一作者： Fabian,Offensperger

第一单位： Department of Biology, University of Konstanz, Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany.

作者： Fabian,Offensperger ^[1] ; Franziska,Müller ^[2] ; Jasmin,Jansen ^[1] ; Daniel,Hammler ^[3] ; Kathrin H,Götz ^[3] ; Andreas,Marx ^[3] ; Carissa L,Sirois ^[4] ; Stormy J,Chamberlain ^[4] ; Florian,Stengel ^[1] ; Martin,Scheffner ^[5]

作者单位： Department of Biology, University of Konstanz, Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany. ^[1] Department of Biology, University of Konstanz, Konstanz, Germany. ^[2] Department of Chemistry, University of Konstanz, Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany. ^[3] Department of Genetics and Genome Sciences, UConn Health, University of Connecticut, Farmington, CT, USA. ^[4] Department of Biology, University of Konstanz, Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany. Electronic address: martin.scheffner@uni-konstanz.de. ^[5]

关键词 Angelman syndrome E6AP UBE3A XL-MS cross-linking coupled to mass spectrometry fluorescence polarization high-throughput screen small-molecule activator ubiquitin ligase

医学主题词 Angelman综合征(Angelman Syndrome);药物设计(Drug Design);酶激活(Enzyme Activation);酶稳定性(Enzyme Stability);点突变(Point Mutation);蛋白质构象(Protein Conformation);小分子化合物库(Small Molecule Libraries);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)

DOI 10.1016/j.chembiol.2020.08.017

PMID 32966807

发布时间 2021-07-05

基金项目

R21 HD091823/HD/NICHD NIH HHS/United States

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交

浏览0

Cell chemical biology

2020年27卷12期

1510-1520.e6页

相似文献

中文期刊
外文期刊
学位论文
会议论文

浏览0

点击下载本期目录封面

Cell chemical biology

2020年27卷12期

1510-1520.e6页

检索历史清除

Identification of Small-Molecule Activators of the Ubiquitin Ligase E6AP/UBE3A and Angelman Syndrome-Derived E6AP/UBE3A Variants.

Cell chemical biology

相似文献

同项目论文

Cell chemical biology

相关期刊

参考文献：
指定格式：	NoteExpress EndNote RefWorks NoteFirst

检索历史 清除

Identification of Small-Molecule Activators of the Ubiquitin Ligase E6AP/UBE3A and Angelman Syndrome-Derived E6AP/UBE3A Variants.

Cell chemical biology

相似文献

同项目论文

Cell chemical biology

相关期刊

检索历史清除