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MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons.

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第一作者： Mette,Habekost

第一单位： Department of Biomedicine, Aarhus University, 8000C Aarhus, Denmark; Danish Research Institute of Translational Neuroscience, Nordic EMBL Partnership for Molecular Medicine, Aarhus University, 8000C Aarhus, Denmark.

作者： Mette,Habekost ^[1] ; Arne Lund,Jørgensen ^[2] ; Per,Qvist ^[3] ; Mark,Denham ^[4]

作者单位： Department of Biomedicine, Aarhus University, 8000C Aarhus, Denmark; Danish Research Institute of Translational Neuroscience, Nordic EMBL Partnership for Molecular Medicine, Aarhus University, 8000C Aarhus, Denmark. ^[1] Department of Biomedicine, Aarhus University, 8000C Aarhus, Denmark. ^[2] Department of Biomedicine, Aarhus University, 8000C Aarhus, Denmark; Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8000C Aarhus, Denmark; Centre for Integrative Sequencing, iSEQ, Aarhus University, 8000C Aarhus, Denmark; Centre for Genomics and Personalized Medicine, CGPM, Aarhus University, 8000C Aarhus, Denmark. ^[3] Department of Biomedicine, Aarhus University, 8000C Aarhus, Denmark; Danish Research Institute of Translational Neuroscience, Nordic EMBL Partnership for Molecular Medicine, Aarhus University, 8000C Aarhus, Denmark. Electronic address: mden@dandrite.au.dk. ^[4]

关键词 Direct reprogramming Disease modelling MicroRNA Neuronal conversion Porcine induced neurons Regenerative medicine

医学主题词动物(Animals);成纤维细胞(Fibroblasts);微RNAs(MicroRNAs);神经元(Neurons);猪(Swine);转录因子(Transcription Factors)

DOI 10.1016/j.scr.2020.101984

PMID 32971463

发布时间 2021-06-21

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