Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment.

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第一作者： Lizhou,Xu

第一单位： Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, United Kingdom.

作者： Lizhou,Xu ^[1] ; Farid N,Faruqu ^[1] ; Yau M,Lim ^[1] ; Kee Y,Lim ^[1] ; Revadee,Liam-Or ^[1] ; Adam A,Walters ^[1] ; Paul,Lavender ^[2] ; David,Fear ^[2] ; Claire M,Wells ^[3] ; Julie,Tzu-Wen Wang ^[1] ; Khuloud T,Al-Jamal ^[4]

作者单位： Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, United Kingdom. ^[1] Department of Respiratory Medicine and Allergy, School of Immunology & Microbial Sciences, King's College London, St. Thomas Street, London, SE1 9RT, United Kingdom. ^[2] Comprehensive Cancer Centre, Faculty of Life Sciences & Medicine, King's College London, New Hunts House, Guy's Campus, London, SE1 1UL, United Kingdom. ^[3] Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, United Kingdom. Electronic address: khuloud.al-jamal@kcl.ac.uk. ^[4]

关键词 Exosome PAK4 Pancreatic cancer Therapeutics siRNA delivery

主题词动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);外泌体(Exosomes);小鼠(Mice);胰腺肿瘤(Pancreatic Neoplasms);RNA干扰(RNA Interference);p21活化激酶类(p21-Activated Kinases)

DOI 10.1016/j.biomaterials.2020.120369

PMID 32977209

发布时间 2021-05-14

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