Development and validation of a simple and versatile method for the quantification of everolimus loaded in H-ferritin nanocages using UHPLC-MS/MS.

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作者： Cristina,Sottani ^[1] ; Elena,Grignani ^[2] ; Serena,Mazzucchelli ^[3] ; Arianna,Bonizzi ^[4] ; Fabio,Corsi ^[5] ; Sara,Negri ^[6] ; Federica,Prati ^[7] ; Enrica,Calleri ^[8] ; Danilo,Cottica ^[9]

作者单位： Environmental Research Center, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy. Electronic address: cristina.sottani@icsmaugeri.it. ^[1] Environmental Research Center, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy. Electronic address: elena.grignani@icsmaugeri.it. ^[2] Nanomedicine Laboratory, Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy. Electronic address: serena.mazzucchelli@unimi.it. ^[3] Nanomedicine Laboratory, Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy. Electronic address: arianna.bonizzi@unimi.it. ^[4] Nanomedicine Laboratory, Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy; Breast Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy. Electronic address: fabio.corsi@unimi.it. ^[5] Environmental Research Center, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy. Electronic address: sara.negri@icsmaugeri.it. ^[6] Department of Drug Sciences, University of Pavia, Viale Taramelli 12, Pavia, Italy. Electronic address: federica.prati01@universitadipavia.it. ^[7] Department of Drug Sciences, University of Pavia, Viale Taramelli 12, Pavia, Italy. Electronic address: enrica.calleri@unipv.it. ^[8] Environmental Research Center, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy. Electronic address: danilo.cottica@icsmaugeri.it. ^[9]

关键词 Cytoplasm Everolimus H-ferritin (HFn)Nanopharmaceutical Protein precipitation UHPLC-ESI-MS/MS

主题词脱辅铁蛋白质类(Apoferritins);色谱法, 高压液相(Chromatography, High Pressure Liquid);免疫抑制剂(Immunosuppressive Agents);结果可重复性(Reproducibility of Results);光谱法, 质量, 电喷雾电离(Spectrometry, Mass, Electrospray Ionization);串联质谱法(Tandem Mass Spectrometry)

DOI 10.1016/j.jpba.2020.113644

PMID 32987250

发布时间 2021-06-17

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