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Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases.

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第一作者: Cian J,Lynch
第一单位: Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.;Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
作者单位: Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.;Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. [1] ProteoRed-ISCIII Proteomics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. [2] Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.;MRC Laboratory of Molecular Biology, Biomedical Campus, Cambridge, UK. [3] Department of Medical Sciences and Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal. [4] Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. [5] Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain. [6] Maintenance of Transcriptional Repression by Polycomb Proteins, Institut Curie, Paris, France. [7] Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. [8] Stem Cell and Brain Research Institute, Univ Lyon, Université Lyon 1, INSERM U1208, Bron, France. [9] Transgenic Mice Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. [10] IGMM, University of Montpellier, CNRS, Inserm, Montpellier, France. [11] Bioinformatics-Biostatistics Unit, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. [12] Cancer Epigenetics and Nanomedicine Laboratory, Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Institute of Oncology of Asturias (IUOPA), ISPA-Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, Spain. [13] Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain.;Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Barcelona, Spain.;Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. [14] Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.;Division of Biology and Biological Engineering, Caltech, Pasadena, CA, USA. [15] Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. manuel.serrano@irbbarcelona.org.;Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. manuel.serrano@irbbarcelona.org.;Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. manuel.serrano@irbbarcelona.org. [16]
DOI 10.1038/s41556-020-0573-1
PMID 32989249
发布时间 2022-10-22
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