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Systemic iron reduction by venesection alters the gut microbiome in patients with haemochromatosis.

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第一作者： Bhavika,Parmanand

第一单位： Quadram Institute, Norwich, UK.;University of East Anglia, Norwich, UK.

作者： Bhavika,Parmanand ^[1] ; Michael,Watson ^[2] ; Karen J,Boland ^[3] ; Narayan,Ramamurthy ^[4] ; Victoria,Wharton ^[2] ; Alireza,Morovat ^[5] ; Elizabeth K,Lund ^[6] ; Jane,Collier ^[2] ; Gwenaelle,Le Gall ^[6] ; Lee,Kellingray ^[7] ; Susan,Fairweather-Tait ^[6] ; Jeremy F,Cobbold ^[2] ; Arjan,Narbad ^[7] ; John D,Ryan ^[8]

作者单位： Quadram Institute, Norwich, UK.;University of East Anglia, Norwich, UK. ^[1] Translational Gastroenterology Unit, University of Oxford, Oxford, UK.;NIHR Oxford Biomedical Research Centre, Oxford, UK. ^[2] Department of Gastroenterology, Beaumont Hospital/Royal College of Surgeons in Ireland, Dublin, Ireland. ^[3] Translational Gastroenterology Unit, University of Oxford, Oxford, UK. ^[4] Department of Clinical Biochemistry, Oxford University Hospitals Foundation Trust, Oxford, UK. ^[5] University of East Anglia, Norwich, UK. ^[6] Quadram Institute, Norwich, UK. ^[7] Translational Gastroenterology Unit, University of Oxford, Oxford, UK.;Hepatology Unit, Beaumont Hospital/Royal College of Surgeons in Ireland, Dublin, Ireland. ^[8]

关键词 ALT, alanine aminotransferase CRP, C-reactive protein FAAS, flame atomic absorption spectrophotometry GI, gastrointestinal HFE, hyperferritinaemia HH, hereditary haemachromatosis Haemochromatosis Iron LDA, linear discriminant analysis LEfSe, linear discriminant analysis effect size Microbiome TSP, 3-(trimethylsilyl)-propionate-d4 Venesection WCC, white cell count

DOI 10.1016/j.jhepr.2020.100154

PMID 32995714

发布时间 2025-05-30

基金项目

BBS/E/F/00044453/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom BBS/E/F/000PR10356/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom

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Systemic iron reduction by venesection alters the gut microbiome in patients with haemochromatosis.

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Systemic iron reduction by venesection alters the gut microbiome in patients with haemochromatosis.

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