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Extensive heterogeneity in somatic mutation and selection in the human bladder.

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第一作者: Andrew R J,Lawson
第一单位: Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
作者单位: Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK. [1] Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.;Department of Hematology, Erasmus University Medical Center, Rotterdam 3015 GD, Netherlands. [2] Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. [3] Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.;NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. [4] Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.;Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. [5] Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK. [6] The Royal Melbourne Hospital, Parkville, Victoria 3010, Australia.;Department of Surgery, The University of Melbourne, Parkville, Victoria 3010, Australia. [7] Academic Urology Group, Department of Surgery and Oncology, University of Cambridge, Cambridge CB2 0QQ, UK.;Cambridge Urology Translational Research and Clinical Trials Office, University of Cambridge CB2 0QQ, UK. [8] Department of Pathology, Royal Papworth Hospital NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge CB2 0AY, UK. [9] European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton CB10 1SD, UK. [10] Mobile Genomes and Disease, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain. [11] Mobile Genomes and Disease, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain.;Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain.;The Biomedical Research Centre (CINBIO), University of Vigo, Vigo 36310, Spain. [12] Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.;Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK. [13] Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.;Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK. [14] Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK. im3@sanger.ac.uk. [15]
DOI 10.1126/science.aba8347
PMID 33004514
发布时间 2025-05-30
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Science (New York, N.Y.)

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