A computational guided, functional validation of a novel therapeutic antibody proposes Notch signaling as a clinical relevant and druggable target in glioma.

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作者： Dayana,Herrera-Rios ^[1] ; Guanzhang,Li ^[2] ; Dilaware,Khan ^[3] ; Julia,Tsiampali ^[1] ; Ann-Christin,Nickel ^[1] ; Philippe,Aretz ^[1] ; Michael,Hewera ^[1] ; Abiagail Kora,Suwala ^[1] ; Tao,Jiang ^[4] ; Hans-Jakob,Steiger ^[5] ; Marcel Alexander,Kamp ^[3] ; Sajjad,Muhammad ^[1] ; Daniel,Hänggi ^[1] ; Jarek,Maciaczyk ^[1] ; Wei,Zhang ^[1] ; Ulf Dietrich,Kahlert ^[6]

作者单位： Neurosurgical Clinic, Medical Faculty, Heinrich-Heine University Duesseldorf, Moorenstrasse 5, 40225, Dusseldorf, Germany. ^[1] Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University Duisburg-Essen, 45147, Essen, Germany. ^[2] Beijing Neurosurgical Institute, Capital Medical University, Beijing, China. ^[3] Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany. ^[4] Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), Duesseldorf, Germany. ^[5] Department of Neurosurgery, University of Bonn, Bonn, Germany. ^[6] Neurosurgical Clinic, Medical Faculty, Heinrich-Heine University Duesseldorf, Moorenstrasse 5, 40225, Dusseldorf, Germany. mail@ulf-kahlert.com. ^[7] Beijing Neurosurgical Institute, Capital Medical University, Beijing, China. mail@ulf-kahlert.com. ^[8] DKTK, German Cancer Consortium, Essen/Duesseldorf, Germany. mail@ulf-kahlert.com. ^[9]