Parallel Single-Cell RNA-Seq and Genetic Recording Reveals Lineage Decisions in Developing Embryoid Bodies.

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作者： Ik Soo,Kim ^[1] ; Jingyi,Wu ^[1] ; Gilbert J,Rahme ^[1] ; Sofia,Battaglia ^[1] ; Atray,Dixit ^[2] ; Elizabeth,Gaskell ^[1] ; Huidong,Chen ^[1] ; Luca,Pinello ^[1] ; Bradley E,Bernstein ^[3]

作者单位： Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. ^[1] Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. ^[2] Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: bernstein.bradley@mgh.harvard.edu. ^[3]

关键词 differentiation embryogenesis lineage tracing single-cell RNA sequencing stem cells

主题词细胞分化(Cell Differentiation);细胞谱系(Cell Lineage);DNA甲基化(DNA Methylation);拟胚体(Embryoid Bodies);人类(Humans)

DOI 10.1016/j.celrep.2020.108222

PMID 33027665

发布时间 2021-09-15

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