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Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells.

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第一作者： Matthew B,Johnson

第一单位： Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.

作者： Matthew B,Johnson ^[1] ; Kashyap A,Patel ^[1] ; Elisa,De Franco ^[1] ; William,Hagopian ^[2] ; Michael,Killian ^[2] ; Timothy J,McDonald ^[3] ; Timothy I M,Tree ^[4] ; Clara,Domingo-Vila ^[5] ; Michelle,Hudson ^[6] ; Suzanne,Hammersley ^[6] ; Rebecca,Dobbs ^[6] ; EXE-T1D Consortium ^[1] ; Sian,Ellard ^[1] ; Sarah E,Flanagan ^[1] ; Andrew T,Hattersley ^[7] ; Richard A,Oram

作者单位： Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. ^[1] Pacific Northwest Research Institute, Seattle, WA, USA. ^[2] Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.;Blood Sciences, Royal Devon & Exeter NHS Foundation Trust, Exeter, UK. ^[3] Department of Immunobiology, School of Immunobiology & Microbial Sciences, Kings College London, London, UK.;NIHR Biomedical Research Centre Guys and St Thomas' NHS Foundation Trust and Kings College London, London, UK. ^[4] Department of Immunobiology, School of Immunobiology & Microbial Sciences, Kings College London, London, UK. ^[5] Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.;National Institute for Health Exeter Research Clinical Research Facility, Royal Devon & Exeter NHS Foundation Trust, Exeter, UK. ^[6] Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. R.Oram@exeter.ac.uk. ^[7]

关键词 Autoimmunity Genetic risk score Neonatal diabetes Type 1 diabetes