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首页> Cancer chemotherapy and pharmacology> Targeting MALAT1 induces DNA damage and sensitize non-small cell lung cancer cells to cisplatin by repressing BRCA1.

Targeting MALAT1 induces DNA damage and sensitize non-small cell lung cancer cells to cisplatin by repressing BRCA1.

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作者： Jinghua,Huang ^[1] ; Changxiu,Lin ^[2] ; Hai,Dong ^[3] ; Zhengri,Piao ^[1] ; Chunhua,Jin ^[4] ; Hengmin,Han ^[5] ; Dongchun,Jin ^[6]

作者单位： Department of Radiation Oncology, Affiliated Hospital of Yanbian University, Yanji, 133000, Jilin, China. ^[1] Central Laboratory, Affiliated Hospital of Yanbian University, Yanji, 133000, Jilin, China. ^[2] Department of Plastic Surgery, Affiliated Hospital of Yanbian University, Yanji, 133000, Jilin, China. ^[3] Department of Clinical Laboratory, Affiliated Hospital of Yanbian University, Yanji, 133000, Jilin, China. ^[4] Department of Oncology, Affiliated Hospital of Yanbian University, No. 1327 Juzi Road, Yanji, 133000, Jilin, China. ^[5] Agricultural College of Yanbian University, Yanji, 133002, Jilin, China. jindongchun@aliyun.com. ^[6]

关键词 DNA repair Long non-coding RNA MALAT1 Non-small cell lung cancer microRNA

主题词抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);BRCA1蛋白质(BRCA1 Protein);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞系, 肿瘤(Cell Line, Tumor);顺铂(Cisplatin);计算生物学(Computational Biology);DNA损伤(DNA Damage);抗药性, 肿瘤(Drug Resistance, Neoplasm);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因敲低技术(Gene Knockdown Techniques);人类(Humans);肺肿瘤(Lung Neoplasms);微RNAs(MicroRNAs);RNA, 小分子干扰(RNA, Small Interfering);增量调节(Up-Regulation)

DOI 10.1007/s00280-020-04152-7

PMID 33030583

发布时间 2021-05-20

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Cancer chemotherapy and pharmacology

Cancer chemotherapy and pharmacology

2020年86卷5期

663-672页

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