Design, synthesis, molecular docking study, and antibacterial evaluation of some new fluoroquinolone analogues bearing a quinazolinone moiety.

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作者： Maryam,Norouzbahari ^[1] ; Somayeh,Salarinejad ^[2] ; Mümtaz,Güran ^[1] ; Gizem,Şanlıtürk ^[1] ; Zahra,Emamgholipour ^[3] ; Hamid Reza,Bijanzadeh ^[2] ; Mahsa,Toolabi ^[4] ; Alireza,Foroumadi ^[5]

作者单位： Faculty of Medicine, Eastern Mediterranean University, Famagusta, Northern Cyprus, via Mersin 10, Turkey. ^[1] Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. ^[2] Department of Chemistry, Faculty of Medicine, Eastern Mediterranean University, Famagusta, Northern Cyprus, via Mersin 10, Turkey. ^[3] Department of Environmental Sciences, Faculty of Natural Resources and Marine Sciences, Tarbiat Modares University, Tehran, Iran. ^[4] Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ^[5] Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. aforoumadi@yahoo.com. ^[6] Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran. aforoumadi@yahoo.com. ^[7]

关键词 2-methylquinazolin-4(3H)-one Antibacterial activity Antibiotic resistance Fluoroquinolones (FQs)Nucleophilic reaction