Combined Inhibition of SHP2 and MEK Is Effective in Models of NF1-Deficient Malignant Peripheral Nerve Sheath Tumors.
第一作者:
Jiawan,Wang
第一单位:
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
作者:
主题词
动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);抗药性, 肿瘤(Drug Resistance, Neoplasm);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);人类(Humans);小鼠, 裸(Mice, Nude);丝裂原激活蛋白激酶激酶类(Mitogen-Activated Protein Kinase Kinases);神经鞘肿瘤(Nerve Sheath Neoplasms);神经纤维瘤(Neurofibroma);神经纤维素1(Neurofibromin 1);蛋白质酪氨酸磷酸酶, 非受体11型(Protein Tyrosine Phosphatase, Non-Receptor Type 11);吡啶酮类(Pyridones);嘧啶酮类(Pyrimidinones);小分子化合物库(Small Molecule Libraries);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);ras蛋白质类(ras Proteins)
DOI
10.1158/0008-5472.CAN-20-1365
PMID
33032988
发布时间
2021-06-28
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Cancer research
5367-5379页
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