The MDM2 inhibitor CGM097 combined with the BET inhibitor OTX015 induces cell death and inhibits tumor growth in models of neuroblastoma.

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作者： Tyler,Maser ^[1] ; Joseph,Zagorski ^[1] ; Shannon,Kelly ^[1] ; Anna,Ostrander ^[1] ; Austin,Goodyke ^[1] ; Abhinav,Nagulapally ^[1] ; Jeffrey,Bond ^[1] ; Yeonhee,Park ^[2] ; Giselle,Saulnier Sholler ^[1]

作者单位： Pediatric Oncology Translational Research Program, Helen DeVos Children's Hospital, Grand Rapids, MI, USA. ^[1] Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA. ^[2] College of Human Medicine, Michigan State University, Grand Rapids, MI, USA. ^[3]

关键词 BET MDM2 MYC MYCN neuroblastoma p53

主题词乙酰苯胺类(Acetanilides);动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);细胞凋亡(Apoptosis);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);半胱氨酸天冬氨酸蛋白酶7(Caspase 7);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);药物协同作用(Drug Synergism);酶激活(Enzyme Activation);女(雌)性(Female);杂环化合物, 3环(Heterocyclic Compounds, 3-Ring);人类(Humans);异喹啉类(Isoquinolines);小鼠(Mice);肿瘤移植(Neoplasm Transplantation);神经母细胞瘤(Neuroblastoma);哌嗪类(Piperazines);蛋白质类(Proteins);原癌基因蛋白质c-mdm2(Proto-Oncogene Proteins c-mdm2);原癌基因蛋白质c-myc(Proto-Oncogene Proteins c-myc);信号传导(Signal Transduction);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)

DOI 10.1002/cam4.3407

PMID 33034426

发布时间 2021-05-05

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Cancer medicine

2020年9卷21期

8144-8158页

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The MDM2 inhibitor CGM097 combined with the BET inhibitor OTX015 induces cell death and inhibits tumor growth in models of neuroblastoma.

Cancer medicine

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Cancer medicine

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The MDM2 inhibitor CGM097 combined with the BET inhibitor OTX015 induces cell death and inhibits tumor growth in models of neuroblastoma.

Cancer medicine

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Cancer medicine

相关期刊

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