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Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy.

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第一作者: Adam S,Darwich
第一单位: Logistics and Informatics in Health Care, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), KTH Royal Institute of Technology, SE-141 57 Huddinge, Sweden.
作者单位: Logistics and Informatics in Health Care, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), KTH Royal Institute of Technology, SE-141 57 Huddinge, Sweden. [1] Department of Clinical Pharmacology, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia.;Centre for Medicine Use and Safety, Monash University, Melbourne, Victoria 3052, Australia.;Certara, Princeton, New Jersey 08540, USA. [2] Centre for Evidence Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford OX2 6GG, United Kingdom. [3] Centre for Applied Pharmacokinetic Research, The University of Manchester, Manchester M13 9PT, United Kingdom; email: amin.rostami@manchester.ac.uk. [4] School of Pharmacy, University of Otago, Dunedin 9054, New Zealand. [5] Geneva Platelet Group, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.;Division of General Internal Medicine, Geneva University Hospitals, CH-1211 Geneva, Switzerland. [6] Geneva Platelet Group, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland. [7] Inera AB, Swedish Association of Local Authorities and Regions, SE-118 93 Stockholm, Sweden. [8] Drug Safety Research & Development, Pfizer Inc., Groton, Connecticut 06340, USA. [9] Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, Florida 32827, USA. [10] School of Pharmacy, The University of Sydney, Sydney, New South Wales 2006, Australia. [11] Certara, Princeton, New Jersey 08540, USA.;Centre for Applied Pharmacokinetic Research, The University of Manchester, Manchester M13 9PT, United Kingdom; email: amin.rostami@manchester.ac.uk. [12]
医学主题词 人类(Humans)
DOI 10.1146/annurev-pharmtox-033020-113257
PMID 33035445
发布时间 2021-09-09
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Annual review of pharmacology and toxicology

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