A Multi-Omics Approach Identifies Key Regulatory Pathways Induced by Long-Term Zinc Supplementation in Human Primary Retinal Pigment Epithelium.

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作者： Eszter,Emri ^[1] ; Elod,Kortvely ^[2] ; Sascha,Dammeier ^[3] ; Franziska,Klose ^[3] ; David,Simpson ^[4] ; Eye-Risk,Consortium ^[5] ; Anneke I,Den Hollander ^[3] ; Marius,Ueffing ^[4] ; Imre,Lengyel

作者单位： Wellcome Wolfson Institute for Experimental Medicine, Queen's University of Belfast, Belfast BT97BL, Northern Ireland, UK.;Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland. ^[1] Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.;Institute for Ophthalmic Research, University of Tubingen, D-72076 Tubingen, Germany. ^[2] Institute for Ophthalmic Research, University of Tubingen, D-72076 Tubingen, Germany. ^[3] Wellcome Wolfson Institute for Experimental Medicine, Queen's University of Belfast, Belfast BT97BL, Northern Ireland, UK. ^[4] Departments of Ophthalmology and Genetics, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands. ^[5]

关键词 TGFB1 age-related macular degeneration gene set enrichment proteome retinal pigment epithelium secretome transcriptome zinc