Blockage of Store-Operated Ca<sup>2+</sup> Influx by Synta66 is Mediated by Direct Inhibition of the Ca<sup>2+</sup> Selective Orai1 Pore.

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作者： Linda,Waldherr ^[1] ; Adela,Tiffner ^[2] ; Deepti,Mishra ^[3] ; Matthias,Sallinger ^[2] ; Romana,Schober ^[1] ; Irene,Frischauf ^[2] ; Tony,Schmidt ^[2] ; Verena,Handl ^[1] ; Peter,Sagmeister ^[4] ; Manuel,Köckinger ^[5] ; Isabella,Derler ^[5] ; Muammer,Üçal ^[2] ; Daniel,Bonhenry ^[4] ; Silke,Patz ^[3] ; Rainer,Schindl ^[4]

作者单位： Gottfried Schatz Research Centre, Medical University of Graz, A-8010 Graz, Austria. ^[1] Institute of Biophysics, JKU Life Science Centre, Johannes Kepler University Linz, A-4020 Linz, Austria. ^[2] Centre for Nanobiology and Structural Biology, Academy of Sciences of the Czech Republic, 373 33 Nové Hrady, Czech Republic. ^[3] Department of Neurosurgery, Medical University of Graz, A-8010 Graz, Austria. ^[4] Institute of Chemistry, University of Graz, Heinrichstraße 28, A-8010 Graz, Austria. ^[5]

关键词 Ca2+, SOCE GBM Orai STIM Synta66 binding docking glioblastoma multiforme pocket pore

DOI 10.3390/cancers12102876

PMID 33036292

发布时间 2023-09-28

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