When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response.

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第一作者： Matías,González-Quiroz

第一单位： Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health, and Metabolism (GERO), University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1242, Chemistry, Oncogenesis, Stress, and Signaling Laboratory, Université of Rennes 1, Rennes, France; Centre de Lutte contre le Cancer Eugène Marquis, Rennes, France.

作者： Matías,González-Quiroz ^[1] ; Alice,Blondel ^[2] ; Alfredo,Sagredo ^[3] ; Claudio,Hetz ^[4] ; Eric,Chevet ^[2] ; Rémy,Pedeux ^[5]

作者单位： Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health, and Metabolism (GERO), University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1242, Chemistry, Oncogenesis, Stress, and Signaling Laboratory, Université of Rennes 1, Rennes, France; Centre de Lutte contre le Cancer Eugène Marquis, Rennes, France. ^[1] Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1242, Chemistry, Oncogenesis, Stress, and Signaling Laboratory, Université of Rennes 1, Rennes, France; Centre de Lutte contre le Cancer Eugène Marquis, Rennes, France. ^[2] Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health, and Metabolism (GERO), University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile. ^[3] Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health, and Metabolism (GERO), University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; The Buck Institute for Research in Aging, Novato, CA 94945, USA. ^[4] Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1242, Chemistry, Oncogenesis, Stress, and Signaling Laboratory, Université of Rennes 1, Rennes, France; Centre de Lutte contre le Cancer Eugène Marquis, Rennes, France. Electronic address: remy.pedeux@univ-rennes1.fr. ^[5]

关键词 ATM DNA damage response IRE1α PERK proteostasis unfolded protein response

主题词动物(Animals);DNA损伤(DNA Damage);内质网(Endoplasmic Reticulum);基因组不稳定性(Genomic Instability);人类(Humans);模型, 生物学(Models, Biological);信号传导(Signal Transduction)

DOI 10.1016/j.tcb.2020.09.002

PMID 33036871

发布时间 2021-09-24

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准确一般字义偏差语意偏离译文作用小提交