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JEM: A joint test to estimate the effect of multiple genetic variants on DNA methylation.

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第一作者： Chloé,Sarnowski

第一单位： Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.

作者： Chloé,Sarnowski ^[1] ; Tianxiao,Huan ^[2] ; Deepti,Jain ^[3] ; Chunyu,Liu ^[4] ; Chen,Yao ^[2] ; Roby,Joehanes ^[5] ; Daniel,Levy ^[2] ; Josée,Dupuis ^[1]

作者单位： Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. ^[1] Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.;The Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. ^[2] Department of Biostatistics, University of Washington, Seattle, Washington, USA. ^[3] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.;Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.;The Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. ^[4] Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.;The Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.;Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts, USA. ^[5]

关键词 SNP-set effect estimation genomic annotation multimarker test single nucleotide polymorphisms

医学主题词 DNA甲基化(DNA Methylation);人类(Humans);线性模型(Linear Models);连锁不平衡(Linkage Disequilibrium);模型, 遗传学(Models, Genetic);表型(Phenotype)

DOI 10.1002/gepi.22369

PMID 33038041

发布时间 2025-05-30

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准确一般字义偏差语意偏离译文作用小提交