Lower cardiac output is associated with neurodegeneration among older adults with normal cognition but not mild cognitive impairment.

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第一作者： Elizabeth E,Moore

第一单位： Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA.;Medical Scientist Training Program, School of Medicine, Vanderbilt University, Nashville, TN, USA.

作者： Elizabeth E,Moore ^[1] ; Dandan,Liu ^[2] ; Corey W,Bown ^[3] ; Hailey A,Kresge ^[3] ; Deepak K,Gupta ^[4] ; Kimberly R,Pechman ^[5] ; Lisa A,Mendes ^[4] ; L Taylor,Davis ^[6] ; Katherine A,Gifford ^[5] ; Adam W,Anderson ^[7] ; Thomas J,Wang ^[4] ; Bennett A,Landman ^[8] ; Timothy J,Hohman ^[5] ; Angela L,Jefferson ^[9]

作者单位： Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA.;Medical Scientist Training Program, School of Medicine, Vanderbilt University, Nashville, TN, USA. ^[1] Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA.;Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. ^[2] Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA. ^[3] Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. ^[4] Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA.;Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. ^[5] Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA.;Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. ^[6] Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. ^[7] Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.;Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.;Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA. ^[8] Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA. angela.jefferson@vumc.org.;Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. angela.jefferson@vumc.org.;Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. angela.jefferson@vumc.org. ^[9]

关键词 Brain MRI Cardiac output Grey matter Neurodegeneration White matter

主题词老年人(Aged);脑(Brain);心排血量(Cardiac Output);认知(Cognition);弥散张量成像(Diffusion Tensor Imaging);人类(Humans);磁共振成像(Magnetic Resonance Imaging)

DOI 10.1007/s11682-020-00398-0

PMID 33040257

发布时间 2024-10-25

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