Potent Synergistic Interactions between Lopinavir and Azole Antifungal Drugs against Emerging Multidrug-Resistant Candida auris.

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作者： Hassan E,Eldesouky ^[1] ; Ehab A,Salama ^[1] ; Nadia A,Lanman ^[2] ; Tony R,Hazbun ^[3] ; Mohamed N,Seleem ^[4]

作者单位： Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.;Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA. ^[1] Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.;Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA. ^[2] Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA. ^[3] Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA seleem@vt.edu.;Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA. ^[4]

关键词 ATP bioluminescence assay Candida auris HIV protease inhibitors Nile red efflux assay azole resistance glucose transporters glucose-induced acidification assay

主题词抗真菌药(Antifungal Agents);氮杂茂类(Azoles);念珠菌属(Candida);氟康唑(Fluconazole);人类(Humans);微生物敏感性试验(Microbial Sensitivity Tests);药用制剂(Pharmaceutical Preparations)

DOI 10.1128/AAC.00684-20

PMID 33046487

发布时间 2024-08-09

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