Efficacy of Telavancin in Comparison to Linezolid in a Porcine Model of Severe Methicillin-Resistant Staphylococcus aureus Pneumonia.

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第一作者： D,Battaglini

第一单位： Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.

作者： D,Battaglini ^[1] ; A,Motos ^[2] ; G,Li Bassi ^[3] ; H,Yang ^[4] ; F,Pagliara ^[1] ; M,Yang ^[5] ; E,Aguilera Xiol ^[6] ; A,Meli ^[4] ; J,Bobi ^[1] ; G,Frigola ^[5] ; T,Senussi ^[6] ; F,Idone ^[4] ; C,Travierso ^[7] ; C,Chiurazzi ^[1] ; L,Fernandez-Barat ^[6] ; M,Rigol ^[1] ; J,Ramirez ^[2] ; P,Pelosi ^[3] ; D,Chiumello ^[1] ; M,Antonelli ^[6] ; D P,Nicolau ^[4] ; J,Bringue ^[1] ; A,Artigas ^[5] ; L,Guerrero ^[6] ; D,Soy ^[4] ; A,Torres ^[1]

作者单位： Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain. ^[1] Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy. ^[2] Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, Genoa, Italy. ^[3] University of Barcelona, Barcelona, Spain. ^[4] Centro de Investigación en Red de Enfermedades Respiratorias, Madrid, Spain. ^[5] Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. ^[6] BITRECS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. ^[7] University of Milan, Milan, Italy. ^[8] Departamento de Anatomía Patológica, Hospital Clínic de Barcelona, Barcelona, Spain. ^[9] Department of Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. ^[10] Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy. ^[11] Università Cattolica del Sacro Cuore, Rome, Italy. ^[12] Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA. ^[13] Department of Intensive Care Medicine, CIBER Enfermedades Respiratorias, Corporacion Sanitaria Universitaria Parc Tauli, Autonomous University of Barcelona, Sabadell, Spain. ^[14] Division of Medicines, Pharmacy Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain. ^[15] Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain atorres@clinic.cat. ^[16]

关键词 MRSA animal models linezolid mechanical ventilation pig porcine model severe pneumonia telavancin

主题词氨基糖苷类(Aminoglycosides);动物(Animals);抗菌药(Anti-Bacterial Agents);耐甲氧西林金黄色葡萄球菌(Methicillin-Resistant Staphylococcus aureus);肺炎, 葡萄球菌性(Pneumonia, Staphylococcal);猪(Swine)

DOI 10.1128/AAC.01009-20

PMID 33046500

发布时间 2022-05-31

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