Protein Sub-Visible Particle and Free Radical formation of a Freeze-Dried Monoclonal Antibody Formulation During Dropping.

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第一作者： Wei-Jie,Fang

第一单位： Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China; Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou, 310016 China. Electronic address: wjfang@zju.edu.cn.

作者： Wei-Jie,Fang ^[1] ; Jia-Wei,Liu ^[2] ; Hong-Jian,Zheng ^[2] ; Bin-Bin,Shen ^[2] ; Xinyu,Wang ^[3] ; Yi,Kong ^[4] ; Zhen-Yi,Jing ^[2] ; Jian-Qing,Gao ^[5]

作者单位： Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China; Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou, 310016 China. Electronic address: wjfang@zju.edu.cn. ^[1] Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China; Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou, 310016 China. ^[2] Department of Chemistry, Zhejiang University, Hangzhou, 310013 China. ^[3] The First People's Hospital of Xiaoshan District, Hangzhou, 311200 China. ^[4] Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China. ^[5]

关键词 Aggregation Dropping Electron paramagnetic resonance Free radical Micro-flow imaging Protein sub-visible particle g-force

主题词抗体, 单克隆(Antibodies, Monoclonal);化学, 药物(Chemistry, Pharmaceutical);药物稳定性(Drug Stability);自由基(Free Radicals);冷冻干燥法(Freeze Drying)

DOI 10.1016/j.xphs.2020.10.008

PMID 33049261

发布时间 2021-06-17

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