Structural and functional characterization of engineered bifunctional fusion proteins of CD39 and CD73 ectonucleotidases.
第一作者:
Elizabeth H,Zhong
第一单位:
Department of Anesthesia, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.;Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
作者:
医学主题词
5'-核苷酸酶(5'-Nucleotidase);腺嘌呤核苷酸类(Adenine Nucleotides);消炎药(Anti-Inflammatory Agents);腺苷三磷酸双磷酸酶(Apyrase);GPI连接蛋白质类(GPI-Linked Proteins);HEK293细胞(HEK293 Cells);人类(Humans);氢离子浓度(Hydrogen-Ion Concentration);水解作用(Hydrolysis);动力学(Kinetics);血小板聚集(Platelet Aggregation);血小板聚集抑制剂(Platelet Aggregation Inhibitors);蛋白质构象(Protein Conformation);蛋白质工程(Protein Engineering);重组融合蛋白质类(Recombinant Fusion Proteins);信号传导(Signal Transduction);构效关系(Structure-Activity Relationship);底物特异性(Substrate Specificity)
DOI
10.1152/ajpcell.00430.2020
PMID
33052071
发布时间
2022-07-16
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