Modular metabolite assembly in <i>Caenorhabditis elegans</i> depends on carboxylesterases and formation of lysosome-related organelles.

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第一作者： Henry H,Le

第一单位： Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States.

作者： Henry H,Le ^[1] ; Chester Jj,Wrobel ^[1] ; Sarah M,Cohen ^[2] ; Jingfang,Yu ^[1] ; Heenam,Park ^[2] ; Maximilian J,Helf ^[1] ; Brian J,Curtis ^[1] ; Joseph C,Kruempel ^[3] ; Pedro Reis,Rodrigues ^[1] ; Patrick J,Hu ^[4] ; Paul W,Sternberg ^[2] ; Frank C,Schroeder ^[1]

作者单位： Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States. ^[1] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States. ^[2] Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, United States. ^[3] Departments of Medicine and Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, United States. ^[4]

关键词 C. elegans ascarosides biochemistry biosynthesis chemical biology metabolomics modular metabolites natural products small molecule signaling