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A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer.

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第一作者： Patrick A,Ott

第一单位： Dana Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. Electronic address: patrick_ott@dfci.harvard.edu.

作者： Patrick A,Ott ^[1] ; Siwen,Hu-Lieskovan ^[2] ; Bartosz,Chmielowski ^[2] ; Ramaswamy,Govindan ^[3] ; Aung,Naing ^[4] ; Nina,Bhardwaj ^[5] ; Kim,Margolin ^[6] ; Mark M,Awad ^[7] ; Matthew D,Hellmann ^[8] ; Jessica J,Lin ^[9] ; Terence,Friedlander ^[10] ; Meghan E,Bushway ^[11] ; Kristen N,Balogh ^[11] ; Tracey E,Sciuto ^[11] ; Victoria,Kohler ^[11] ; Samantha J,Turnbull ^[11] ; Rana,Besada ^[11] ; Riley R,Curran ^[11] ; Benjamin,Trapp ^[11] ; Julian,Scherer ^[11] ; Asaf,Poran ^[11] ; Dewi,Harjanto ^[11] ; Dominik,Barthelme ^[11] ; Ying Sonia,Ting ^[11] ; Jesse Z,Dong ^[11] ; Yvonne,Ware ^[11] ; Yuting,Huang ^[11] ; Zhengping,Huang ^[11] ; Amy,Wanamaker ^[11] ; Lisa D,Cleary ^[11] ; Melissa A,Moles ^[11] ; Kelledy,Manson ^[11] ; Joel,Greshock ^[11] ; Zakaria S,Khondker ^[11] ; Ed,Fritsch ^[11] ; Michael S,Rooney ^[11] ; Mark,DeMario ^[11] ; Richard B,Gaynor ^[11] ; Lakshmi,Srinivasan ^[12]

作者单位： Dana Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. Electronic address: patrick_ott@dfci.harvard.edu. ^[1] Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. ^[2] Washington University School of Medicine, St. Louis, MO, USA. ^[3] Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[4] Tisch Cancer Institute, Icahn School of Medicine, New York, NY, USA. ^[5] Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA. ^[6] Dana Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. ^[7] Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[8] Cancer Center, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA. ^[9] Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, CA, USA. ^[10] Neon Therapeutics/BioNTech US, Cambridge, MA, USA. ^[11] Neon Therapeutics/BioNTech US, Cambridge, MA, USA. Electronic address: lakshmi.srinivasan@biontech.us. ^[12]

关键词 NEO-PV-01 T cell anti-PD-1 cancer vaccine checkpoint inhibitor epitope spread immunotherapy metastatic cancer neoantigen personalized vaccine