Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation.

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作者： Kristina E,Steffens ^[1] ; Marvin B,Brenner ^[1] ; Michael U,Hartig ^[1] ; Marius,Monschke ^[1] ; Karl G,Wagner ^[2]

作者单位： Department of Pharmaceutics, University of Bonn, Gerhard-Domagk-Str.3, 53121 Bonn, Germany. ^[1] Department of Pharmaceutics, University of Bonn, Gerhard-Domagk-Str.3, 53121 Bonn, Germany. Electronic address: kgwagner@uni-bonn.de. ^[2]

关键词 Binder distribution Flowability High-shear mixer Melt granulation Porosity Tabletability Twin-screw granulator

主题词药物调剂(Drug Compounding);辅药(Excipients);粒子大小(Particle Size);多孔性(Porosity);片剂(Tablets);工艺学, 制药(Technology, Pharmaceutical)

DOI 10.1016/j.ijpharm.2020.119941

PMID 33065223

发布时间 2021-06-17

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