A solution for low-dose feeding in continuous pharmaceutical processes.

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作者： Stephan,Sacher ^[1] ; Nikolaus,Heindl ^[2] ; Jesús Alberto,Afonso Urich ^[2] ; Julia,Kruisz ^[2] ; Johannes G,Khinast ^[3]

作者单位： Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13/2, 8010 Graz, Austria. Electronic address: stephan.sacher@rcpe.at. ^[1] Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13/2, 8010 Graz, Austria. ^[2] Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13/2, 8010 Graz, Austria; Institute for Process and Particle Engineering, Graz University of Technology, Inffeldgasse 13/3, 8010 Graz, Austria. ^[3]

关键词 Continuous feeding Hot melt extrusion Low dose API Micro-feeding

主题词热温度(Hot Temperature);药用制剂(Pharmaceutical Preparations);粉剂(Powders);结果可重复性(Reproducibility of Results);工艺学, 制药(Technology, Pharmaceutical)

DOI 10.1016/j.ijpharm.2020.119969

PMID 33068692

发布时间 2021-06-17

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