Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models.

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第一作者： Giovanna,Cenini

第一单位： Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Venusberg-Campus 1, D-53127 Bonn, Germany.

作者： Giovanna,Cenini ^[1] ; Matthias,Hebisch ^[2] ; Vira,Iefremova ^[1] ; Lea J,Flitsch ^[1] ; Yannik,Breitkreuz ^[3] ; Rudolph E,Tanzi ^[2] ; Doo Yeon,Kim ^[2] ; Michael,Peitz ^[4] ; Oliver,Brüstle ^[5]

作者单位： Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Venusberg-Campus 1, D-53127 Bonn, Germany. ^[1] Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. ^[2] Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Venusberg-Campus 1, D-53127 Bonn, Germany; LIFE & BRAIN GmbH, Cellomics Unit, Venusberg-Campus 1, D-53127 Bonn, Germany. ^[3] Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Venusberg-Campus 1, D-53127 Bonn, Germany; Cell Programming Core Facility, University of Bonn Medical Faculty & University Hospital Bonn, Venusberg-Campus 1, D-53127 Bonn, Germany. ^[4] Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Venusberg-Campus 1, D-53127 Bonn, Germany. Electronic address: brustle@uni-bonn.de. ^[5]

关键词 3D matrix Alzheimer’s disease Organoids Spheroids Xenograft iPSC

主题词阿尔茨海默病(Alzheimer Disease);动物(Animals);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);移植, 异种(Transplantation, Heterologous)

DOI 10.1016/j.mcn.2020.103568

PMID 33068718

发布时间 2021-10-13

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