The response of PIK3CA/KRAS-mutant colorectal cancer stem-like cells to RGD-peptide FraC produced by the strawberry anemone: A promising water-soluble peptide-based inhibitor of metastasis-driver gene CXCR4, stem cell regulatory genes and self-renewal.

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第一作者： Roya,Sarkhosh-Inanlou

第一单位： Department of Cellular and Molecular Biotechnology, Institute of Biotechnology, Urmia University, Urmia, Iran. Electronic address: sarkhosh_1991@yahoo.com.

作者： Roya,Sarkhosh-Inanlou ^[1] ; Mehdi,Imani ^[2] ; Mohammad Reza,Sam ^[3]

作者单位： Department of Cellular and Molecular Biotechnology, Institute of Biotechnology, Urmia University, Urmia, Iran. Electronic address: sarkhosh_1991@yahoo.com. ^[1] Department of Cellular and Molecular Biotechnology, Institute of Biotechnology, Urmia University, Urmia, Iran; Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Electronic address: m.imani@urmia.ac.ir. ^[2] Department of Cellular and Molecular Biotechnology, Institute of Biotechnology, Urmia University, Urmia, Iran; Department of Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran; Department of Biotechnology, Artemia and Aquaculture Research Institute, Urmia University, Urmia, Iran. Electronic address: m.sam@urmia.ac.ir. ^[3]

关键词 Chemokine receptor 4 (CXCR4)Colorectal cancer (CRC)Colorectal cancer stem cells (CRCSCs)Fragacea toxin C (FraC)Kirsten rat sarcoma viral oncogene homolog (KRAS)Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA)Pluripotency genes RGD-peptide