Systems biology analysis of the Clostridioides difficile core-genome contextualizes microenvironmental evolutionary pressures leading to genotypic and phenotypic divergence.

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作者： Charles J,Norsigian ^[1] ; Heather A,Danhof ^[2] ; Colleen K,Brand ^[3] ; Numan,Oezguen ^[2] ; Firas S,Midani ^[3] ; Bernhard O,Palsson ^[4] ; Tor C,Savidge ^[2] ; Robert A,Britton ^[3] ; Jennifer K,Spinler ^[1] ; Jonathan M,Monk ^[4]

作者单位： Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. ^[1] Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA. ^[2] Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, TX, USA. ^[3] Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. ^[4] Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. jmonk@ucsd.edu. ^[5]

主题词环境(Environment);进化, 分子(Evolution, Molecular);基因组, 细菌(Genome, Bacterial);基因组学(Genomics);基因型(Genotype);表型(Phenotype);种系发生(Phylogeny);系统生物学(Systems Biology)

DOI 10.1038/s41540-020-00151-9

PMID 33082337

发布时间 2022-04-05

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NPJ systems biology and applications

2020年6卷1期

31页

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Systems biology analysis of the Clostridioides difficile core-genome contextualizes microenvironmental evolutionary pressures leading to genotypic and phenotypic divergence.

NPJ systems biology and applications

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NPJ systems biology and applications

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Systems biology analysis of the Clostridioides difficile core-genome contextualizes microenvironmental evolutionary pressures leading to genotypic and phenotypic divergence.

NPJ systems biology and applications

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NPJ systems biology and applications

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